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Effects of GABA‐B agonist baclofen on esophageal motility: Studies using high‐resolution manometry
Author(s) -
Hung JuiSheng,
Yi ChihHsun,
Liu TsoTsai,
Lei WeiYi,
Wong MingWun,
Chen ChienLin
Publication year - 2019
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.13716
Subject(s) - high resolution manometry , baclofen , agonist , esophageal motility disorder , partial agonist , motility , medicine , chemistry , gastroenterology , pharmacology , reflux , receptor , biology , microbiology and biotechnology , disease
Background/Aim Baclofen inhibits transient lower esophageal sphincter (LES) relaxation. This study aimed to investigate the effect of baclofen on esophageal peristaltic function and contraction reserve in healthy adults using high‐resolution manometry (HRM). Methods Fifteen subjects underwent HRM with ten water swallows and five multiple rapid swallows (MRS) 90 minutes after oral intake of either baclofen or placebo on separate days at least 1 week apart. HRM parameters assessed included esophagogastric junction contractile integral (EGJ‐CI), resting LES pressure, 4‐second integrated relaxation pressure (IRP‐4s), distal contractile integral (DCI), distal latency, peristaltic breaks, resting upper esophageal sphincter (UES) pressure, and contractile response to MRS. Results Baclofen significantly increased EGJ‐CI ( P = .007), IRP‐4s ( P = .003), and LES pressure ( P = .004). UES pressure, latency, and DCI were similar between baclofen and placebo ( P = .87, P = .84, and P = .54, respectively). There was no difference in contractile response and peristaltic augmentation following MRS between baclofen and placebo (93% vs 100%, P = .30; 53% vs. 73%, P = .26, respectively). Conclusions Baclofen increases resting LES pressure and EGJ barrier function, but has no effect on primary peristalsis or contraction reserve.