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Effect of attention bias modification on brain function and anxiety in patients with irritable bowel syndrome: A preliminary electroencephalogram and psycho‐behavioral study
Author(s) -
Tayama J.,
Saigo T.,
Ogawa S.,
Takeoka A.,
Hamaguchi T.,
Hayashida M.,
Fukudo S.,
Shirabe S.
Publication year - 2017
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.13131
Subject(s) - irritable bowel syndrome , anxiety , medicine , electroencephalography , psychology , intervention (counseling) , clinical psychology , psychiatry
Abstract Background Gastrointestinal symptoms of irritable bowel syndrome ( IBS ) show a reciprocal relationship with anxiety. In this intervention‐based study, we investigated the utility of attention bias modification ( ABM ) therapy in patients with IBS . We hypothesized that IBS ‐related electroencephalographic abnormalities would be normalized after ABM therapy. Methods Seventeen patients with IBS and 13 healthy subjects completed five ABM intervention sessions over a 2‐month period. Each session included 128 ABM trials, resulting in a total of 640 trials across the intervention period. For each trial, subjects viewed a pair of facial expression images and were instructed to indicate the position of the neutral face as quickly and accurately as possible by pressing one of two buttons on a button box. Electroencephalography data (alpha and beta power percentages) were collected during the 1st and 5th sessions. Key Results Generalized estimating equations of relative alpha power revealed a significant effect of period was identified at O2 ( P =.036). Paired t tests revealed that ABM significantly increased relative alpha power at O2 in patients with IBS . Generalized estimating equation of relative beta power revealed a significant effect of the group × period interaction was identified at Pz ( P =.035). Paired t tests revealed that ABM significantly decreased relative beta power at Pz in patients with IBS . Conclusions & Inferences Attention bias modification may normalize brain function related to attention and anxiety in patients with IBS .