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Postreflux swallow‐induced peristaltic wave index and nocturnal baseline impedance can link PPI ‐responsive heartburn to reflux better than acid exposure time
Author(s) -
Frazzoni L.,
Frazzoni M.,
Bortoli N.,
Tolone S.,
Furnari M.,
Martinucci I.,
Bertani H.,
Marchi S.,
Conigliaro R.,
Fuccio L.,
Savarino V.,
Savarino E.
Publication year - 2017
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.13116
Subject(s) - heartburn , reflux , medicine , receiver operating characteristic , logistic regression , gastroenterology , area under the curve , nocturnal , peristalsis , proton pump inhibitor , multivariate analysis , disease
Background Acid exposure time ( AET ) is considered the most useful parameter to predict response of reflux‐related heartburn to medical or surgical treatment. However, recent studies showed high rates of heartburn response to proton pump inhibitor ( PPI ) therapy in patients with normal AET . We aimed to compare the efficacy of postreflux swallow‐induced peristaltic wave ( PSPW ) index and mean nocturnal baseline impedance ( MNBI ) with AET in linking PPI ‐responsive heartburn to reflux. Methods Off‐therapy impedance‐ pH tracings from 425 patients, 317 with PPI ‐responsive and 108 with PPI ‐refractory heartburn were blindly re‐analyzed. Demographic and endoscopic characteristics, conventional impedance‐ pH variables, PSPW index, and MNBI were assessed with multivariate logistic regression to identify factors independently associated with PPI responsiveness. Prediction models were developed to assess the strength of reflux linkage with factors independently associated with PPI responsiveness by calculating the area under the curve ( AUC ) at receiver‐operating‐characteristic ( ROC ) analysis. Key Results At multivariate logistic regression analysis, AET , MNBI , and PSPW index were the only factors independently associated with PPI responsiveness, abnormal values found in 60%, 76%, and 92% of PPI ‐responsive cases ( P <.017). At ROC analysis, PSPW index ( AUC :.794, P =.002) and MNBI ( AUC : 0.742, P =.003), both separately and combined ( AUC : 0.811, P <.001) linked reflux with PPI ‐responsiveness better than AET ( AUC : 0.687). Conclusions & Inferences AET , PSPW index, and MNBI are independently associated with PPI ‐responsive heartburn. PSPW index and MNBI can link PPI ‐responsive heartburn to reflux better than AET and should become part of the standard analysis of impedance‐ pH tracings.