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Stress and brain functional changes in patients with Crohn's disease: A functional magnetic resonance imaging study
Author(s) -
Agostini A.,
Ballotta D.,
Righi S.,
Moretti M.,
Bertani A.,
Scarcelli A.,
Sartini A.,
Ercolani M.,
Nichelli P.,
Campieri M.,
Benuzzi F.
Publication year - 2017
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.13108
Subject(s) - functional magnetic resonance imaging , medicine , stroop effect , neuroscience , disinhibition , disease , magnetic resonance imaging , psychology , cognition , radiology
Background In Crohn's disease ( CD ) patients, stress is believed to influence symptoms generation. Stress may act via central nervous system pathways to affect visceral sensitivity and motility thus exacerbating gastrointestinal symptoms. The neural substrate underpinning these mechanisms needs to be investigated in CD . We conducted an explorative functional magnetic resonance imaging ( fMRI ) study in order to investigate potential differences in the brain stress response in CD patients compared to controls. Methods 17 CD patients and 17 healthy controls underwent a fMRI scan while performing a stressful task consisting in a Stroop color‐word interference task designed to induce mental stress in the fMRI environment. Key Results Compared to controls, in CD patients the stress task elicited greater blood oxygen level dependent ( BOLD ) signals in the midcingulate cortex ( MCC ). Conclusions & Inferences The MCC integrate “high” emotional processes with afferent sensory information ascending from the gut. In light of these integrative functions, the stress‐evoked MCC hyperactivity in CD patients might represent a plausible neural substrate for the association between stress and symptomatic disease. The MCC dysfunction might be involved in mechanisms of central disinhibition of nociceptive inputs leading to amplify the visceral sensitivity. Finally, the stress‐evoked MCC hyperactivity might affect the regulation of intestinal motility resulting in exacerbation of disease symptoms and the autonomic and neuroendocrine regulation of inflammation resulting in enhanced inflammatory activity.