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A magnetic resonance imaging study of gastric motor function in patients with dyspepsia associated with Ehlers‐Danlos Syndrome‐Hypermobility Type: A feasibility study
Author(s) -
Menys A.,
Keszthelyi D.,
Fitzke H.,
Fikree A.,
Atkinson D.,
Aziz Q.,
Taylor S. A.
Publication year - 2017
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.13090
Subject(s) - gastric emptying , magnetic resonance imaging , medicine , gastroenterology , cohort , joint hypermobility , ehlers–danlos syndrome , motility , stomach , surgery , radiology , physical therapy , biology , genetics
Background The clinical use of Magnetic Resonance Imaging ( MRI ) for investigating gastric motor function in dyspepsia is limited, largely due to protocol complexity, cost and limited availability. In this study, we explore the feasibility of a sub 60‐minute protocol using a water challenge to assess gastric emptying, motility and accommodation in a cohort of Ehlers‐Danlos Syndrome‐Hypermobility type ( EDS ‐ HT ) patients presenting with dyspepsia. Methods Nine EDS ‐ HT patients (mean age 33, range: 26‐50 all female) with a history of dyspepsia were recruited together with nine‐matched controls. Subjects fasted for 6 hours prior to MRI . A baseline anatomical and motility scan was performed after which the subjects ingested 300 mL water. The anatomical and motility scans were then repeated every 10 minutes to a total of 60 minutes. Gastric emptying time, motility, and accommodation were calculated based on the observations of two observers for each EDS ‐ HT subject and compared to their matched control using paired statistics. Key Results Median motility increase following the water challenge was lower in EDS ‐ HT subjects (11%, range: 0%‐22%) compared to controls (22%, range: 13%‐56%), P =.03. Median gastric emptying time was non‐significantly decreased in EDS ‐ HT subjects (12.5 minutes, range: 6‐27) compared to controls (20 minutes, range: 7‐30), P =.15. Accommodation was non‐significantly reduced in EDS ‐ HT subjects (56% increase, range: 32%‐78%) compared to healthy controls (67% increase, range: 52%‐78%), P =.19. Conclusions & Inferences This study demonstrates the feasibility of a water challenge MRI protocol to evaluate gastric physiology in the clinical setting. Motility differences between EDS ‐ HT and controls are worthy of further investigation.