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Multiple functional gastrointestinal disorders linked to gastroesophageal reflux and somatization: A population‐based study
Author(s) -
Choung R. S.,
Richard Locke G.,
Schleck C. D.,
Zinsmeister A. R.,
Talley N. J.
Publication year - 2017
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.13041
Subject(s) - medicine , irritable bowel syndrome , somatization , population , reflux , checklist , odds ratio , constipation , disease , psychiatry , psychology , anxiety , environmental health , cognitive psychology
Background It is unknown why functional gastrointestinal disorders ( FGID s) overlap and limited information exists on risk factors for those with overlap. Our aim was to estimate the prevalence of combinations of FGID s including reflux ( FGID s‐gastroesophageal reflux [ GER ]), and evaluate potential risk factors for people with multiple disorders in a representative US community. Methods A population‐based study was conducted by mailing a valid GI symptom questionnaire to an age‐ and gender‐stratified random sample of residents of Olmsted County, MN . Rome III definitions were used to identify people with FGID s, and GER was defined by weekly or more frequent heartburn or acid regurgitation. The prevalence of people meeting multiple symptom complexes was estimated. Moreover, potential risk factors for people with multiple disorders were evaluated. Key Results A total of 3548 people provided data for each of the necessary symptom questions (mean age: 61±16 years, 54% female). Among these 3548 subjects, 2009 (57%) had no FGID s‐ GER , 906 (26%) had a pure FGID ‐ GER , 372 (10%) had 2 FGID s‐ GER , and 261 (7%) had 3 or more FGID s‐ GER . Somatization as assessed by a higher Somatic Symptom Checklist score ( OR =3.3, 95% CI [2.7,4.1]) was associated with an increased odds for those with 3 or more FGID s‐ GER compared to subjects with a pure FGID ‐ GER adjusting for age and gender. Conclusions and Inferences Symptom complex overlap is common rather than rare in the community. GER is an integral symptom complex associated with both upper and lower FGID s. Somatization is a strong risk factor for multiple FGID s.