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Clinical application of a gadolinium‐based capsule as an MRI contrast agent in slow transit constipation diagnostics
Author(s) -
Zhi M.,
Zhou Z.,
Chen H.,
Xiong F.,
Huang J.,
He H.,
Zhang M.,
Su M.,
Gao X.,
Hu P.
Publication year - 2017
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.13020
Subject(s) - medicine , constipation , capsule , gadolinium , magnetic resonance imaging , gastroenterology , nuclear medicine , radiology , botany , biology , materials science , metallurgy
Background As a traditional method for the assessment of colon dynamics, radio‐opaque markers ( ROM s) are limited in clinical use because of their ionizing radiation. We compared the accuracy and applicability of gadolinium‐based capsules with ROM s in the measurement of colon dynamics in healthy controls and slow transit constipation ( STC ) patients. Methods Seven patients with STC and nine healthy controls under a normal diet orally consumed ROM s and gadolinium‐based capsules simultaneously. All subjects underwent X‐ray and magnetic resonance imaging ( MRI ). Healthy control images were acquired at 12, 24, and 48 h, and STC patient images were acquired at 24, 48, and 72 h. The scores based on the position of the labeling capsules and ROM s in the colon and the colon transit times ( CTT s) in the two groups were compared. Key Results The CTT s obtained via the ROM s were 34.7±17.4 and 67.3±6.5 h in the healthy controls and STC patients, respectively ( P <.05). The CTT s obtained via MRI were 30.9±15.9 and 74.1±7.2 h in the healthy controls and STC patients, respectively ( P <.05). The CTT s of the STC patients were significantly longer than the healthy controls. The correlation ( r s ) between the scores based on the position of the labeling capsule and ROM s in the healthy group and the STC patients was .880 ( P <.05) and .889 ( P <.05), respectively. Conclusions and Inferences As a MRI contrast label, gadolinium‐based capsules exhibit results comparable to ROM s in colon motility measurements.