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Gastrointestinal disorders in joint hypermobility syndrome/Ehlers‐Danlos syndrome hypermobility type: A review for the gastroenterologist
Author(s) -
Beckers A. B.,
Keszthelyi D.,
Fikree A.,
Vork L.,
Masclee A.,
Farmer A. D.,
Aziz Q.
Publication year - 2017
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.13013
Subject(s) - joint hypermobility , hypermobility (travel) , medicine , irritable bowel syndrome , ehlers–danlos syndrome , pathophysiology , connective tissue , connective tissue disorder , dermatology , gastroenterology , physical therapy , pathology
Background Joint hypermobility syndrome ( JHS )/Ehlers‐Danlos syndrome hypermobility type ( EDS ‐ HT ) is the most common hereditary non‐inflammatory disorder of connective tissue, characterized by a wide range of symptoms, mainly joint hyperextensibility and musculoskeletal symptoms. A majority of patients also experiences gastrointestinal ( GI ) symptoms. Furthermore, JHS / EDS ‐ HT has specifically been shown to be highly prevalent in patients with functional GI disorders, such as functional dyspepsia and irritable bowel syndrome. Purpose The aim of this review was to examine the nature of GI symptoms and their underlying pathophysiology in JHS / EDS ‐ HT . In addition, we consider the clinical implications of the diagnosis and treatment of JHS / EDS ‐ HT for practicing clinicians in gastroenterology. Observations summarized in this review may furthermore represent the first step toward the identification of a new pathophysiological basis for a substantial subgroup of patients with functional GI disorders.