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A prospective study on symptom generation according to spicy food intake and TRPV 1 genotypes in functional dyspepsia patients
Author(s) -
Lee S.Y.,
Masaoka T.,
Han H. S.,
Matsuzaki J.,
Hong M. J.,
Fukuhara S.,
Choi H. S.,
Suzuki H.
Publication year - 2016
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.12841
Subject(s) - trpv , medicine , retching , gastroenterology , bloating , capsaicin , stomach , nausea , transient receptor potential channel , receptor , trpv1
Background Capsaicin is an ingredient of red peppers that binds to transient receptor potential vanilloid subtype 1 ( TRPV 1), and Koreans eat more capsaicin‐rich food than do Japanese. This study aimed to compare symptom generation according to TRPV 1 genotypes and the intake of spicy foods. Methods Consecutive functional dyspepsia ( FD ) patients who were evaluated at Konkuk University Medical Centre (Korea) and Keio University Hospital (Japan) were included. Questionnaires on spicy food intake, patient assessment of gastrointestinal symptoms ( PAGI ‐ SYM ), patient assessment of quality of life, and hospital anxiety and depression scale were provided. Blood was sampled for the detection of TRPV 1 polymorphisms, and upper gastrointestinal endoscopy was performed with biopsies. Key Results Of 121 included subjects, 35 and 28 carried the TRPV 1 CC and GG genotypes, respectively, with the prevalence rates not differing between Japan and Korea. The prevalence of FD subtypes did not differ with the spicy food intake, TRPV 1 genotypes, or Helicobacter pylori infection. Neither TRPV 1 polymorphisms nor H. pylori infections were related to scores on the PAGI ‐ SYM questionnaires, but spicy food intake was positively correlated with the scores for stomach fullness ( p = 0.001) and retching ( p = 0.001). Using the linear regression analysis, stomach fullness was associated with spicy food intake ( p = 0.007), whereas retching was related to younger age ( p < 0.001) and female gender ( p = 0.014). Conclusions & Inferences Upper gastrointestinal symptoms are more common in subjects with a higher consumption of spicy foods, younger age and female gender, regardless of TRPV 1 genotypes and the H. pylori infection status. Capsaicin‐rich foods may induce stomach fullness.