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Postinfectious irritable bowel syndrome after travelers' diarrhea – a cohort study
Author(s) -
SchwilleKiuntke J.,
Enck P.,
Polster A. V.,
Gaile M.,
Kremsner P. G.,
Zanger P.
Publication year - 2015
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.12601
Subject(s) - irritable bowel syndrome , medicine , somatization , anxiety , cohort , hospital anxiety and depression scale , diarrhea , depression (economics) , abdominal pain , cohort study , vomiting , gastroenterology , psychiatry , economics , macroeconomics
Background There is sound evidence for the role of gastrointestinal infections in the development of postinfectious irritable bowel syndrome ( PI ‐ IBS ), but understanding the interaction between mental factors and the infection remains incomplete. This study aims to (i) assess the occurrence of PI ‐ IBS in a cohort of patients with self‐reported travelers' diarrhea ( TD ), (ii) assess risk factors for PI ‐ IBS development, and (iii) investigate the prognosis of PI ‐ IBS after 1 year. Methods Patients consulting the travel clinic at the University Hospital Tuebingen, Germany (in 2009 and 2010) were identified from records and questioned in follow‐ups in 2011 and 2012. We used the Rome III modular questionnaire to assess IBS , the Hospital Anxiety and Depression Scale to assess anxiety and depression, and the Patient Health Questionnaire to assess somatization. Key Results We identified 529 eligible subjects from the clinical records. Of 135 subjects (age: 36.6 ± 14.6 years, 58.5% female) included in the study sample 6.7% (95% CI 3.0–11.1) had PI ‐ IBS . We found more females (88.9% vs 56.3%, p = 0.08) and younger age subjects (mean 29.3 vs 37.1 years, p = 0.02) among the PI ‐ IBS subjects. A multivariable regression model revealed vomiting at baseline and high somatization scores as strong and independent PI ‐ IBS risk factors. One year later PI ‐ IBS occurrence decreased to 3.3% (three cases of 90). Conclusions & Inferences Our findings underline the close linkage of mental and somatic processes for the manifestation of PI ‐ IBS . Screening for psychiatric comorbidities in patients with severe gastrointestinal infections may allow identifying groups at high risk for PI ‐ IBS .