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Quantitative assessment of small bowel motility in patients with Crohn's disease using dynamic MRI
Author(s) -
Hahnemann M. L.,
Nensa F.,
Kinner S.,
Köhler J.,
Gerken G.,
Umutlu L.,
Lauenstein T. C.
Publication year - 2015
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.12558
Subject(s) - motility , inflammatory bowel disease , gastroenterology , magnetic resonance imaging , medicine , gastrointestinal tract , lesion , inflammation , pathology , radiology , disease , biology , genetics
Abstract Background Assessment of motility alterations by functional magnetic resonance imaging ( MRI ) contributes to improved evaluation of inflammatory bowel disease. The aim of the study was to quantify motility in inflammatory bowel segments and to compare motility alterations with MR ‐based parameters for activity of inflammation in Crohn's disease ( CD ). Methods Thirty consecutive patients with CD underwent bowel MRI which included a dynamic sequence for automatic generation of parametric maps facilitating quantification of bowel motility. Mean motility score ( MMS ) of small bowel segments with signs of inflammation was measured and compared with MMS of the whole gastrointestinal tract ( GI tract). MRI ‐based score of inflammatory activity and lesion length were correlated with the MMS ratio of inflammatory small bowel lesion and whole GI tract. Key Results Inflammatory bowel segments showed a mean value of MMS s of 1080, whereas the whole GI tract showed a mean value of MMS s of 2839 ( p < 0.0001). Decrease in motility ranged between 20 and 87% in inflammatory bowel segments compared to the MMS of the whole GI tract. The MMS ratio of an inflammatory small bowel segment and whole GI tract showed negative correlation with MR activity score ( r = −0.5921, p = 0.0003) and length of the lesion ( r = −0.3495, p = 0.0462). Conclusions & Inferences Quantitative assessment of motility alterations by means of motility scoring in small bowel segments affected by CD provides additional information on inflammatory activity.