A ghrelin receptor agonist is an effective colokinetic in rats with diet‐induced constipation
Author(s) -
Pustovit R. V.,
Furness J. B.,
Rivera L. R.
Publication year - 2015
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.12517
Subject(s) - constipation , defecation , distension , ghrelin , agonist , medicine , lubiprostone , endocrinology , receptor , gastroenterology , chronic constipation
Abstract Background Despite constipation being a common problem, the treatments that are available have side effects and are only partly effective. Recent studies show that centrally penetrant ghrelin receptor agonists cause defecation in humans and other species. Here, we describe some features of a rat model of low fiber‐induced constipation, and investigate the effectiveness of the ghrelin agonist, capromorelin. Methods Rats were given low‐fiber diets for 5 weeks. Their colorectal responsiveness to distension and to a behavioral test, water avoidance and colon histology were compared to those of rats on a standard diet. Key Results After the low‐fiber diet, distension of the colon produced fewer propulsive contractions, behaviorally induced defecation was reduced, and the lining of the colorectum was inflamed. However, capromorelin was similarly effective in causing defecation in constipated and non‐constipated rats. Conclusions & Inferences Low‐fiber diet in rats produces a constipation phenotype, characterized by reduced responsiveness of the colorectum to distension and to a behavioral stimulus of defecation, water avoidance. The effectiveness of capromorelin suggests that centrally penetrant ghrelin receptor stimulants may be effective in treating constipation.