Vasoactive intestinal peptide is a local mediator in a gut‐brain neural axis activating intestinal gluconeogenesis | Zendy

De Vadder F. | Zendy; Plessier F. | Zendy; GautierStein A. | Zendy; Mithieux G. | Zendy

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Vasoactive intestinal peptide is a local mediator in a gut‐brain neural axis activating intestinal gluconeogenesis

Author(s) -

De Vadder F.,

Plessier F.,

GautierStein A.,

Mithieux G.

Publication year - 2015

Publication title -

neurogastroenterology and motility

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.489

H-Index - 105

eISSN - 1365-2982

pISSN - 1350-1925

DOI - 10.1111/nmo.12508

Subject(s) - vasoactive intestinal peptide , mediator , peptide , gut–brain axis , neuroscience , chemistry , medicine , biology , endocrinology , neuropeptide , biochemistry , gut flora , receptor

Intestinal gluconeogenesis ( IGN ) promotes metabolic benefits through activation of a gut‐brain neural axis. However, the local mediator activating gluconeogenic genes in the enterocytes remains unknown. We show that (i) vasoactive intestinal peptide ( VIP ) signaling through VPAC 1 receptor activates the intestinal glucose‐6‐phosphatase gene in vivo , (ii) the activation of IGN by propionate is counteracted by VPAC 1 antagonism, and (iii) VIP ‐positive intrinsic neurons in the submucosal plexus are increased under the action of propionate. These data support the role of VIP as a local neuromodulator released by intrinsic enteric neurons and responsible for the induction of IGN through a VPAC 1 receptor‐dependent mechanism in enterocytes.

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