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Vasoactive intestinal peptide is a local mediator in a gut‐brain neural axis activating intestinal gluconeogenesis
Author(s) -
De Vadder F.,
Plessier F.,
GautierStein A.,
Mithieux G.
Publication year - 2015
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.12508
Subject(s) - vasoactive intestinal peptide , mediator , peptide , gut–brain axis , neuroscience , chemistry , medicine , biology , endocrinology , neuropeptide , biochemistry , gut flora , receptor
Intestinal gluconeogenesis ( IGN ) promotes metabolic benefits through activation of a gut‐brain neural axis. However, the local mediator activating gluconeogenic genes in the enterocytes remains unknown. We show that (i) vasoactive intestinal peptide ( VIP ) signaling through VPAC 1 receptor activates the intestinal glucose‐6‐phosphatase gene in vivo , (ii) the activation of IGN by propionate is counteracted by VPAC 1 antagonism, and (iii) VIP ‐positive intrinsic neurons in the submucosal plexus are increased under the action of propionate. These data support the role of VIP as a local neuromodulator released by intrinsic enteric neurons and responsible for the induction of IGN through a VPAC 1 receptor‐dependent mechanism in enterocytes.