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Esophageal acid stimulation alters insular cortex functional connectivity in gastroesophageal reflux disease
Author(s) -
Siwiec R. M.,
Babaei A.,
Kern M.,
Samuel E. A.,
Li S. J.,
Shaker R.
Publication year - 2015
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.12464
Subject(s) - insula , insular cortex , gerd , stimulation , medicine , reflux , heartburn , gastroenterology , anesthesia , psychology , neuroscience , disease
Background The insula plays a significant role in the interoceptive processing of visceral stimuli. We have previously shown that gastroesophageal reflux disease ( GERD ) patients have increased insular cortex activity during esophageal stimulation, suggesting a sensitized esophago‐cortical neuraxis. However, information regarding the functional connectivity ( FC ) of the insula during visceral stimulation is lacking. The primary aim of this study was to investigate the FC of insular subregions during esophageal acid stimulation. Methods Functional imaging data were obtained from 12 GERD patients and 14 healthy subjects during four steady state conditions: (i) presence of transnasal esophageal catheter (pre‐infusion); (ii) neutral solution; (iii) acid infusion; (iv) presence of transnasal esophageal catheter following infusions (post‐infusion). The insula was parcellated into six regions of interest. FC maps between each insular ROI and interoceptive regions were created. Differences in FC between GERD patients and healthy subjects were determined across the 4 study conditions. Key Results All GERD patients experienced heartburn during and after esophageal acidification. Significant differences between GERD patients and healthy subjects were seen in: (i) insula‐thalamic FC (neutral solution infusion, acid infusion, post‐infusion); (ii) insula‐amygdala FC (acid infusion, post‐infusion); (iii) insula‐hippocampus and insula‐cingulate FC (post‐infusion). Conclusions & Inferences Esophageal stimulation in GERD patients revealed significant insular cortex FC differences with regions involved in viscerosensation and interoception. The results of our study provide further evidence that the insula, located at the transition of afferent physiologic information to human feelings, is essential for both visceral homeostasis and the experience of heartburn in GERD patients.