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Heterogeneity of mucosal mast cell infiltration in subgroups of patients with esophageal chest pain
Author(s) -
Lee H.,
Chung H.,
Park J. C.,
Shin S. K.,
lee S. K.,
Lee Y. C.
Publication year - 2014
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.12325
Subject(s) - medicine , irritable bowel syndrome , gastroenterology , esophagus , chest pain , mast cell , immunology
Background Although there is growing evidence that an increase in mucosal mast cells ( MMC s) in the small and large intestine is associated with visceral hypersensitivity, few studies have evaluated MMC s in humans with esophageal symptoms. The aim of this study was to investigate esophageal MMC distribution in patients with non‐cardiac chest pain ( NCCP ) and to examine the association between the number of gut MMC s and other functional gastrointestinal disorders. Methods Forty‐two consecutive NCCP patients and 10 healthy controls completed a questionnaire for bowel symptoms, chest pain intensity score, and psychologic depression. Esophageal, duodenal, and rectal MMC s were identified immunohistochemically and quantified by image analysis. Key Results Numbers of MMC s were significantly higher in NCCP patients vs healthy controls (11.8 ± 5.6 vs 7.6 ± 3.7 MMC s/high‐power field, p = 0.026). In comparison of subgroups classified by 24‐h impedance–pH monitoring, esophageal MMC counts were highest in the hypersensitive esophagus group ( p < 0.01) and were also significantly increased in the functional chest pain group ( p < 0.05). A positive correlation between esophageal and duodenal MMC counts was observed in patients with functional dyspepsia ( FD ; Spearman ρ = 0.604, p = 0.037). In particular, patients with clinical overlap with irritable bowel syndrome showed a strong positive correlation between esophageal and rectal MMC numbers (Spearman ρ = 0.857, p = 0.010). Conclusions & Inferences Among NCCP patients, increased MMC infiltration occurs in subgroups with hypersensitive esophagus and functional chest pain. In subpopulations with overlap with FD or irritable bowel syndrome, esophageal MMC counts demonstrated significant positive correlations with duodenal or rectal MMC counts.