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Background  Previous assessments of colon morphology have relied on tests which were either invasive or used ionizing radiation. We aimed to measure regional volumes of the undisturbed colon in healthy volunteers ( HV ) and patients with diarrhea‐predominant irritable bowel syndrome ( IBS ‐D).    Methods  3D regional (ascending, transverse, and descending) colon volumes were measured in fasting abdominal magnetic resonance ( MR ) images of 75  HV s and 25  IBS ‐D patients. Thirty‐five of the  HV  and all 25  IBS ‐D subjects were fed a standard meal and postprandial  MRI  data obtained over 225 min.    Key Results  Colonic regions were identified and 3D maps from cecum to sigmoid flexure were defined. Fasted regional volumes showed wide variation in both  HV s being (mean ±  SD ) ascending colon ( AC ) 203 ± 75 mL, transverse ( TC ) 198 ± 79 mL, and descending ( DC ) 160 ± 86 mL with no difference from  IBS ‐D subjects ( AC  205 ± 69 mL,  TC  232 ± 100 mL, and  DC  151 ± 71 mL, respectively). The  AC  volume expanded by 10% after feeding (p = 0.007) in the 35  HV  possibly due to increased ileo‐colonic inflow. A later rise in  AC  volume occurred from t = 90 to t = 240 min as the meal residue entered the cecum. In contrast,  IBS ‐D subjects showed a much reduced postprandial response of the  AC  (p < 0.0001) and a greater increase in  TC  volume after 90 min (p = 0.0244) compared to  HV .    Conclusions & Inferences  We have defined a normal range of the regional volumes of the undisturbed colon in fasted and fed states. The  AC  in  IBS ‐D appeared less able to accommodate postprandial inflow which may account for faster colonic transit.

neurogastroenterology and motility

Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea‐predominant irritable bowel syndrome measured using serial  MRI