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Gastric secretion does not affect the reliability of the 13 C‐acetate breath test: A validation of the 13 C‐acetate breath test by magnetic resonance imaging
Author(s) -
Kuyumcu S.,
Goetze O.,
Menne D.,
Treier R.,
Boesiger P.,
Fox M.,
Fried M.,
Schwizer W.,
Steingoetter A.
Publication year - 2013
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.12025
Subject(s) - gastric emptying , exhalation , pentagastrin , breath test , magnetic resonance imaging , nuclear medicine , chemistry , gastroenterology , medicine , stomach , anesthesia , gastric acid , radiology , helicobacter pylori
Background 13 C‐Acetate labeled meals are widely used to determine meal emptying by means of analyzing resulting 13 CO 2 exhalation dynamics. In contrast to the underlying metabolic processes, only few 13 C breath test meal emptying studies have focused on intragastric processes that may alter 13 CO 2 exhalation. This work assessed the effect of enhanced gastric secretion on the reliability of half emptying time ( t 50) measurements by 13 C‐acetate breath test. Methods 13 CO 2 exhalation data were acquired in a double‐blind, randomized, cross‐over gastric emptying study in 12 healthy volunteers receiving either pentagastrin or placebo intravenously. The standard method proposed by Ghoos et al. was applied to calculate t 50 ( t 50_Ghoos) from 13 CO 2 exhalation data, which were compared and tested for agreement to meal half emptying times ( t 50_MV) from concurrent recorded MRI (magnetic resonance imaging) volume data. In addition, the accumulated gastric secretion volumes during infusion as detected by MRI (AUC_SV 60 ) were correlated with the corresponding cumulative percent 13 C doses recovered (cPDR 60 ). Key Results t 50_Ghoos and t 50_MV showed a linear correlation with a slope of 1.1 ± 0.3 ( r 2 = 0.67), however, a positive offset of 136 min for t 50_Ghoos. No correlation was detected between AUC_SV 60 and cPDR 60 ( r 2 = 0.11). Both, breath test and MRI, revealed a prolonged t 50 under pentagastrin infusion with median differences in t 50_Ghoos of 45[28–84] min ( P = 0.002) and t 50_MV of 39[28–52] min ( P = 0.002). Conclusions & Inferences This study suggests that 13 CO 2 exhalation after ingestion of a 13 C‐labeled liquid test meal is not affected by stimulated gastric secretion, but is rather reflecting the dynamics of meal or caloric emptying from the stomach.