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Senile plaque calcification of the lamina circumvoluta medullaris in Alzheimer's disease
Author(s) -
Schober Ralf,
Hilbrich Isabel,
Jäger Carsten,
Holzer Max
Publication year - 2021
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/neup.12742
Subject(s) - senile plaques , pathology , hippocampus , calcification , medicine , anatomy , basal ganglia , basal lamina , neurofibrillary tangle , alzheimer's disease , disease , central nervous system , ultrastructure
Vascular calcification is a common phenomenon in the elderly, predominantly appearing in the basal ganglia and in the lamina circumvoluta medullaris of the hippocampus. Calcifications are not an inherent feature of Alzheimer's disease. On the other hand, a rare presenile type of dementia with symmetrical Fahr‐type calcifications and numerous neurofibrillary tangles without senile plaques has been described by Kosaka in 1994 and was termed “diffuse neurofibrillary tangles with calcification” (DNTC). We here report a case of Alzheimer's disease with calcifications both in the basal ganglia and in the lamina circumvoluta medullaris of the hippocampus, differing from DNTC by the presence of senile plaques. The calcifications in the hippocampus were not only vascular in nature but also covered amyloid‐β‐ and phosphorylated tau‐positive plaque‐like structures that were linearly arranged along the dentate fascia in the CA1 sector, an unusual finding of pathogenetic interest.