Supratentorial ependymoma with   YAP1:FAM118B   fusion: A case report | Zendy

Wang Jian | Zendy; Wang Liang | Zendy; Fu Lin | Zendy; Li QingChang | Zendy; Qiu XueShan | Zendy; Wang EnHua | Zendy; Yu JuanHan | Zendy

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Supratentorial ependymoma with YAP1:FAM118B fusion: A case report

Author(s) -

Wang Jian,

Wang Liang,

Fu Lin,

Li QingChang,

Qiu XueShan,

Wang EnHua,

Yu JuanHan

Publication year - 2021

Publication title -

neuropathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.701

H-Index - 61

eISSN - 1440-1789

pISSN - 0919-6544

DOI - 10.1111/neup.12712

Subject(s) - ependymoma , magnetic resonance imaging , lesion , medicine , medulloblastoma , pathology , radiology

We report a case of a 26‐year‐old Chinese man who had experienced three grand mal seizures in the past two months. Magnetic resonance imaging revealed a relatively well‐circumscribed lesion in the left frontal lobe. A craniotomy with total excision of the tumor was performed. Histopathological investigations confirmed a grade 2 ependymoma according to the World Health Organization classification. Genetic analysis revealed a tumor harboring FAM118B fusion to YAP1 , and no other genetic alterations or methylation of the O 6 ‐methylguanine‐DNA methyltransferase gene promoter were detected. This is the second case report of ependymoma with YAP1:FAM118B fusion.

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