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Supratentorial ependymoma with YAP1:FAM118B fusion: A case report
Author(s) -
Wang Jian,
Wang Liang,
Fu Lin,
Li QingChang,
Qiu XueShan,
Wang EnHua,
Yu JuanHan
Publication year - 2021
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/neup.12712
Subject(s) - ependymoma , magnetic resonance imaging , lesion , medicine , medulloblastoma , pathology , radiology
We report a case of a 26‐year‐old Chinese man who had experienced three grand mal seizures in the past two months. Magnetic resonance imaging revealed a relatively well‐circumscribed lesion in the left frontal lobe. A craniotomy with total excision of the tumor was performed. Histopathological investigations confirmed a grade 2 ependymoma according to the World Health Organization classification. Genetic analysis revealed a tumor harboring FAM118B fusion to YAP1 , and no other genetic alterations or methylation of the O 6 ‐methylguanine‐DNA methyltransferase gene promoter were detected. This is the second case report of ependymoma with YAP1:FAM118B fusion.