Formation of new lymphatic vessels in glioma: An immunohistochemical analysis | Zendy

Meng FanWei | Zendy; Liu FuSheng | Zendy; Liu WenHui | Zendy; Li Li | Zendy; Jie LinLin | Zendy

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Formation of new lymphatic vessels in glioma: An immunohistochemical analysis

Author(s) -

Meng FanWei,

Liu FuSheng,

Liu WenHui,

Li Li,

Jie LinLin

Publication year - 2020

Publication title -

neuropathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.701

H-Index - 61

eISSN - 1440-1789

pISSN - 0919-6544

DOI - 10.1111/neup.12625

Subject(s) - nestin , lymphatic system , pathology , cd34 , glioma , lymphatic endothelium , lymphatic vessel , immunohistochemistry , biology , medicine , cancer research , stem cell , microbiology and biotechnology , cancer , neural stem cell , metastasis , genetics

We investigated the distribution and formation of new lymphatic vessels in gliomas. Specimens from seven glioma cases were analyzed by immunohistochemical staining for CD34, lymphatic endothelial hyaluronic acid receptor 1 (LYVE‐1), prospero‐related homeobox 1 (Prox1), nestin, and hypoxia‐inducible factor 1α (HIF‐1α). Three types of vessels were observed in glioma specimens: LYVE‐1 + lymphatic vessels, CD34 + blood vessels, and LYVE‐1 + /CD34 + blood vessels. Prox1 + /LYVE‐1 + cells were distributed in some lymphatic vessels as well as among vascular endothelial cells and glioma cells. Nestin + cells were scattered throughout the gliomas, and some lymphatic cells also expressed nestin. HIF‐1α + Prox1 + cells were widely distributed within the glioma specimens. The present immunohistochemical analysis revealed upregulation of Prox1 and HIF‐1α in some glioma tissues as well as the differentiation of nestin + tumor stem cells into LYVE‐1 + lymphatic vessels.

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