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Isolated lymphomatoid granulomatosis of the central nervous system: A case report and literature review
Author(s) -
He Chao,
Wang Yunxia,
Zhang Leyi,
Lu Chenglong,
Ge Wei,
Zhang Qingkui,
Gui Qiuping,
Liu Ruozhuo,
Yu Shengyuan
Publication year - 2019
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/neup.12605
Subject(s) - lymphomatoid granulomatosis , pathological , pathology , medicine , central nervous system , infiltration (hvac) , biopsy , disease , lymphoma , physics , thermodynamics , endocrinology
Lymphomatoid granulomatosis (LYG) is an angiocentric and angiodestructive lymphoproliferative disease which can involve multiple organs of the body and is most common in the lungs. Its pathological features are proliferation of large atypical B‐cells related to Epstein–Barr virus, T‐cell infiltration and tissue necrosis. This disease is rare, and LYG which uniquely involves the central nervous system (CNS) is extremely rare. In this paper, we report a case of isolated lymphomatoid granulomatosis of the CNS (iCNS‐LYG) diagnosed by histological biopsy and we review the clinical features of all similar cases reported in the past 46 years. A total of 49 cases of iCNS‐LYG have been reported to date. The clinical, imaging and pathological features of iCNS‐LYG are discussed in combination with a literature review.