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Co‐existent pilocytic astrocytoma with acute B‐cell leukemia within the cerebellum
Author(s) -
Hickman Richard,
LeemanNeill Rebecca,
Rosenblum Marc,
Anderson Richard,
Goldman James
Publication year - 2019
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/neup.12587
Subject(s) - pilocytic astrocytoma , astrocytoma , pathology , medicine , cerebellum , leukemia , histopathology , glioma , cancer research
Pilocytic astrocytomas are the commonest childhood brain tumor. They are typically benign and usually are solitary neoplasms. To our knowledge, only one report of a pilocytic astrocytoma with leukemia has been previously issued. We herein describe the first case with documented histopathology of a 2‐year‐old boy who had a cerebellar pilocytic astrocytoma co‐localized with an acute B‐lymphoblastic leukemia. We speculate that chemotactic migration of leukemic cells to the pilocytic astrocytoma may be partly mediated through vascular endothelial growth factor (VEGF) and VEGF receptors.