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Glioblastoma in adults with neurofibromatosis type I: A report of two cases
Author(s) -
Narasimhaiah Deepti,
Sridutt Bhaadri S,
Thomas Bejoy,
Vilanilam George C
Publication year - 2019
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/neup.12579
Subject(s) - neurofibromatosis , medicine , pilocytic astrocytoma , glioblastoma , pathology , malignant peripheral nerve sheath tumor , neurofibromin 1 , neurofibromatosis type i , presentation (obstetrics) , neurofibroma , astrocytoma , radiology , cancer research
Neurofibromatosis type I (NF1) is a familial tumor syndrome with an autosomal‐dominant inheritance. NF1‐associated tumors often include neurofibromas, malignant peripheral nerve sheath tumors and pilocytic astrocytomas of the optic nerve. The presentation of NF1 patients with glioblastoma is a rare occurrence, with only a handful of cases reported in the literature. We report two cases of glioblastomas occurring in adults with NF1 and briefly review the relevant literature.