BRAF  V600E‐mutated central nervous system tumor with divergent morphological feature – Anaplastic pleomorphic xanthoastrocytoma‐like and astroblastoma‐like | Zendy

Purkait Suvendu | Zendy; Bansal Sumit | Zendy; Malgulwar Prit B. | Zendy

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BRAF V600E‐mutated central nervous system tumor with divergent morphological feature – Anaplastic pleomorphic xanthoastrocytoma‐like and astroblastoma‐like

Author(s) -

Purkait Suvendu,

Bansal Sumit,

Malgulwar Prit B.

Publication year - 2019

Publication title -

neuropathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.701

H-Index - 61

eISSN - 1440-1789

pISSN - 0919-6544

DOI - 10.1111/neup.12527

Subject(s) - pleomorphic xanthoastrocytoma , v600e , pathology , central nervous system , biology , mutation , medicine , cancer research , glioma , gene , astrocytoma , neuroscience , genetics

Mutational analysis of the BRAF gene ( BRAF ), especially BRAF V600E, is gaining much importance in neuro‐oncology practice due to its diagnostic, prognostic and therapeutic implications. This genetic alteration has been described in a wide morphological spectrum of central nervous system tumors. In the present report we describe a BRAF V600E‐mutated tumor with divergent morphological appearance comprising of anaplastic pleomorphic xanthoastrocytoma and astroblastoma. Both of these tumor entities are extremely rare and a combined morphology has not been described till now.

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