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Hydroxychloroquine‐induced autophagic vacuolar myopathy with mitochondrial abnormalities
Author(s) -
Khosa Shaweta,
Khanlou Negar,
Khosa Gurveer S.,
Mishra Shri K.
Publication year - 2018
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/neup.12520
Subject(s) - hydroxychloroquine , medicine , myopathy , muscle biopsy , chloroquine , connective tissue , discontinuation , toxicity , connective tissue disorder , inflammatory myopathy , biopsy , mitochondrial myopathy , pathology , malaria , biology , disease , covid-19 , infectious disease (medical specialty) , biochemistry , mitochondrial dna , gene
Hydroxychloroquine (HCQ) and chloroquine are used worldwide for malaria as well as connective and rheumatological disorders. They have been reported to be linked to myopathy in patients. We report four patients who were receiving HCQ as part of treatment for connective tissue disorder and who presented with myopathy. The muscle biopsy in these patients was consistent with findings of HCQ toxicity. HCQ muscle toxicity is usually self‐limiting after discontinuation of the drug. It also usually tends to be under‐reported due to presence of various confounding factors. This warrants close monitoring and consideration of muscle biopsy as part of initial work up of patients who present with myopathy while receiving HCQ.