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Brainstem astroblastoma with MN1 translocation
Author(s) -
Shin Sun Ah,
Ahn Bokyung,
Kim SeungKi,
Kang Hyoung Jin,
Nobusawa Sumihito,
Komori Takashi,
Park SungHye
Publication year - 2018
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/neup.12514
Subject(s) - glial fibrillary acidic protein , pathology , brainstem , histopathology , fluorescence in situ hybridization , neuroepithelial cell , biology , central nervous system , ependymoma , immunohistochemistry , medicine , neuroscience , neural stem cell , microbiology and biotechnology , stem cell , gene , biochemistry , chromosome
Astroblastoma is a rare glial neoplasm that occurs mostly in the cerebral hemisphere of children, adolescents and young adults. Although astroblastic perivascular pseudorosettes are unique histopathology of this neoplasm, diagnosis is usually challenging. Recently, it was discovered that the meningioma 1 gene ( MN1 )‐altered pediatric central nervous system high‐grade neuroepithelial tumors are actually astroblastomas. This case report presents a rare brainstem astroblastoma, with an unusual immunoprofile: negative for glial fibrillary acidic protein and oligodendrocyte transcription factor 2, but with a robust expression of pancytokeratin and epithelial membrane antigen. The diagnosis was confirmed based on the detection of MN1 rearrangement in a fluorescence in situ hybridization study, in addition to typical histopathology. Here we discuss the diagnostic pitfalls and unclear grading system along with a literature review.