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Autopsy‐proven case of paraneoplastic lower motor neuron disease with sensorimotor neuropathy due to Waldenström's macroglobulinemia
Author(s) -
Suzuki Yasuhiro,
Aizawa Hitoshi,
Sakashita Kento,
Kishi Hideaki,
Nomura Kenta,
Yoshida Kosuke,
Aburakawa Yoko,
Kuroda Kenji,
Murakami Chisato,
Kakinoki Yasutaka,
Kimura Takashi
Publication year - 2018
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/neup.12506
Subject(s) - medicine , pathology , spinal cord , autopsy , motor neuron , macroglobulinemia , lower motor neuron , immunostaining , anatomy , immunohistochemistry , disease , psychiatry , multiple myeloma
We report a case of a male patient with a 19‐year history of monoclonal and later polyclonal gammopathy who subsequently developed tetraparesis, bulbar palsy, and respiratory failure. Autopsy findings showed degeneration of the hypoglossal nuclei, prominent neuronal loss and atrophy in the anterior horn of the whole spinal cord despite the presence of mild astrocytosis, degeneration of the gracilis on one side, and infiltration of inflammatory cells, which included B cells and plasma cells in the anterior and posterior roots of the lumbar spinal cord, iliopsoas muscle, and perivascular area of the cervical cord. On immunostaining, cytoplasmic inclusions of phosphorylated transactivation response DNA‐binding protein of 43 kDa were observed in the motor neurons and astrocytes of the hypoglossal nuclei and whole spinal cord. The final diagnosis was paraneoplastic lower motor neuron disease with sensorimotor neuropathy due to Waldenström's macroglobulinemia.