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Sporadic Creutzfeldt–Jakob disease with glial PrP Res nuclear and perinuclear immunoreactivity
Author(s) -
FernándezVega Ivan,
DíazLucena Daniela,
Azkune Calle Itxaso,
Geijo Maria,
Juste Ramon A.,
Llorens Franc,
Vicente Etxenausia Ikerne,
SantosJuanes Jorge,
Zarranz Imirizaldu Juan Jose,
Ferrer Isidro
Publication year - 2018
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/neup.12505
Subject(s) - immunofluorescence , antibody , pathology , amino acid , histone , microbiology and biotechnology , biology , chemistry , virology , medicine , biochemistry , immunology , gene
Proteinase K‐resistant prion protein (PrP Res ) nuclear and perinuclear immunoreactivity in oligodendrocytes of the frontal cortex is found in one case of otherwise typical sporadic Creutzfeldt‐Jakob disease (sCJD) type VV2a. The PrP nature of the inclusions is validated with several anti‐PrP antibodies directed to amino acids 130–160 (12F10), 109–112 (3F4), 97–102 (8G8) and the octarepeat region (amino acids 59–89: SAF32). Cellular identification and subcellular localization were evaluated with double‐ and triple‐labeling immunofluorescence and confocal microscopy using antibodies against PrP, glial markers, and histone H3. Based on review of the literature and our own experience, this is a very odd situation that deserves further validation in other cases.