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Intraventricular gliosarcoma with dual sarcomatous differentiation: A unique case
Author(s) -
Poyuran Rajalakshmi,
bn Nandeesh,
Reddy Yerasi Varun Kumar,
Savardekar Amey R.
Publication year - 2017
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/neup.12369
Subject(s) - gliosarcoma , pathology , fibrosarcoma , neoplasm , glioblastoma , immunohistochemistry , isocitrate dehydrogenase , sarcoma , biology , heterologous , medicine , cancer research , gene , enzyme , genetics , biochemistry
Gliosarcoma, a variant of isocitrate dehydrogenase‐wildtype glioblastoma, is largely a lobar surfacing neoplasm often with dural attachment. In this biphasic neoplasm, the sarcomatous component usually takes the form of fibrosarcoma or malignant fibrous histiocytoma. Heterologous sarcomatous differentiation is a rare phenomenon. Here, we present a case of gliosarcoma with liposarcomatous and myosarcomatous differentiation in a 68‐year‐old man which was purely intraventricular. This is the first report of such a morphologic pattern in this location. Varied histological components with their immunohistochemical profile are discussed. Of note was the presence of a p53 negative giant cell glioblastoma component, as was the expression in the rest of the tumor.

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