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Characteristics of ganglion cells in pituitary gangliocytomas
Author(s) -
Novello Mariangela,
Gessi Marco,
Doglietto Francesco,
Anile Carmelo,
Lauriola Libero,
Coli Antonella
Publication year - 2017
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/neup.12322
Subject(s) - ganglion , cytokeratin , pathology , pathological , pituitary adenoma , sella turcica , population , pituitary tumors , biology , adenoma , immunohistochemistry , medicine , anatomy , environmental health
The occurrence of ganglion cells in the sella turcica, in association or not with a pituitary adenoma, has been rarely reported. Various names have been employed for this rare entity, gangliocytoma being frequently used and recommended by WHO classification. Expression of cytokeratin in these ganglion cells has been previously occasionally reported, a very intriguing observation raising questions on the possible nature and derivation of these cells. We describe the pathological findings in three cases of growth hormone‐producing adenomas, all sparsely granulated, showing the presence of a ganglion cell population admixed with an adenomatous component. A review of the literature is also provided.