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Primary intracranial low‐grade fibromyxoid sarcoma with FUS gene rearrangement
Author(s) -
Chen Ni,
Gong Jing,
Nie Ling,
Chen Xueqin,
Xu Miao,
Chen Min,
Zhou Qiao
Publication year - 2015
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/neup.12197
Subject(s) - sarcoma , fluorescence in situ hybridization , pathology , medicine , soft tissue sarcoma , trunk , gene , biology , genetics , ecology , chromosome
Low‐grade fibromyxoid sarcoma ( LGFMS ) is a rare sarcoma typically presenting as a deep soft tissue mass in the lower extremities or trunk. Only four cases of primary intracranial LGFMS have been reported in the literature, but none with molecular/cytogenetic data. We report here a new bona fide case confirmed by the characteristic FUS gene rearrangement, as shown by fluorescence in situ hybridization analysis, in addition to typical histopathological findings. This would be the first genetically confirmed report of the extremely rare occurrence of intracranial LGFMS .