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Malignant transformation of craniopharyngioma with detailed follow‐up
Author(s) -
Wang Wei,
Chen XiaoDong,
Bai HongMin,
Liao QiuLin,
Dai Xuejun,
Peng DaYun,
Cao HuiXia
Publication year - 2015
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/neup.12142
Subject(s) - craniopharyngioma , coagulative necrosis , medicine , histopathology , malignancy , pleomorphism (cytology) , calcification , radiology , pathology , immunohistochemistry
A 29‐year‐old male patient was admitted into hospital with the main complaint of progressive visual disturbance. Both CT SCAN and MRI demonstrated a cystic‐solid contrast‐enhancing sellar‐suprasellar mass with obvious calcification. Histopathological examination of the first resected specimen showed a typical appearance of adamantinomatous craniopharyngioma. The patient received gamma knife therapy after his first operation because of partial tumor removal. He experienced two relapses in the subsequent 2 years, for which only surgical resection was performed. The later histopathology presented malignant appearance with tumor cells moderate to severe pleomorphism, hyperchromasia, increased nuclear cytoplastic ratio, high mitotic activity (30/10 high power fields) and focal coagulative necrosis. The patient died 9 months after identification of histologic malignancy. Clinical and histopathological features, biological behavior of one case of malignant craniopharyngioma were discussed, with a brief review of the relevant literature.