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Gastrodin alleviates memory deficits and reduces neuropathology in a mouse model of Alzheimer's disease
Author(s) -
Hu Yikui,
Li Chengyan,
Shen Wei
Publication year - 2014
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/neup.12115
Subject(s) - gastrodin , gastrodia elata , neuroprotection , microglia , neuropathology , genetically modified mouse , medicine , pharmacology , morris water navigation task , neuroinflammation , neuroscience , transgene , disease , chemistry , traditional chinese medicine , immunology , hippocampus , pathology , biology , biochemistry , inflammation , alternative medicine , chromatography , gene
Alzheimer's disease ( AD ) is a progressive, neurodegenerative disease, characterized by excessive accumulation of amyloid‐beta (Aβ) and activation of microglia cells and astrocytes. In this research, we evaluated whether gastrodin, an active component isolated from the rhizome of Gastrodia elata , has neuroprotective effects in a mouse model of AD , Tg2576 mice. Treatment of gastrodin (60 mg/kg for 15 days) significantly improved memory impairments in the M orris water maze test and probe test. Moreover, immunohistochemical and ELISA results indicated that gastrodin significantly attenuated Aβ deposition and glial activation in brains of these transgenic mice. These findings suggested that gastrodin exerted neuroprotective activity via anti‐inflammatory and anti‐amyloidogenic effects and that gastrodin may be a potential option for AD therapy.