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An autopsy case of incipient P ick's disease: Immunohistochemical profile of early‐stage P ick body formation
Author(s) -
Miki Yasuo,
Mori Fumiaki,
Tanji Kunikazu,
Kurotaki Hidekachi,
Kakita Akiyoshi,
Takahashi Hitoshi,
Wakabayashi Koichi
Publication year - 2014
Publication title -
neuropathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 61
eISSN - 1440-1789
pISSN - 0919-6544
DOI - 10.1111/neup.12104
Subject(s) - immunohistochemistry , stage (stratigraphy) , subclinical infection , pathology , brainstem , autopsy , disease , medicine , anatomy , biology , paleontology
There is little immunohistochemical information about the early stage of P ick body formation, due to the extremely limited opportunities of studying P ick's disease at the incipient or subclinical stage. We report a 62‐year‐old man without any clinical manifestations of P ick's disease, who died of B ‐cell lymphoma of the brainstem. Post mortem examination revealed many P ick bodies without obvious neuronal loss mainly in the left frontal and temporal lobes. Three brains of patients with typical P ick's disease (disease duration: 7, 11 and 16 years) were also examined. P ick bodies were immunopositive for phosphorylated tau and 3‐repeat tau, and less consistently for p62 in both incipient and typical cases. In the incipient case, borderline positivity for ubiquitin was evident in only a few P ick bodies, whereas in the typical cases many P ick bodies showed obvious positivity for ubiquitin. These findings suggest that P ick bodies are rarely ubiquitinated in the early stage of P ick body formation.