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Tissue typing for kidney transplantation for the general nephrologist
Author(s) -
Mulley William R,
Hudson Fiona,
Lee Darren,
Holdsworth Rhonda F
Publication year - 2019
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.13637
Subject(s) - tissue typing , medicine , human leukocyte antigen , typing , transplantation , immunology , sophistication , histocompatibility , kidney transplantation , histocompatibility testing , nephrology , antigen , kidney , genetics , biology , social science , sociology
ABSTRACT Tissue typing is the process by which an individual's human leukocyte antigens (HLA) are determined. In transplantation, this vital process allows the immunologic or rejection risk of a donor–recipient pairing to be assessed through reviewing their HLA matching and whether any anti‐HLA antibodies present in recipient serum are donor specific. Tissue typing has increased in sophistication over time which has allowed a deeper appreciation of the antigenically important parts of HLA and increased the complexity of determining immunologic risk.