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Is arterial calcification in children and adolescents with end‐stage renal disease a rare finding?
Author(s) -
Menezes Fernanda L,
KochNogueira Paulo C,
Val Maria L.D.M.,
Pestana José O.M.,
Jorgetti Vanda,
Reis Marlene A,
Reis Monteiro Maria L.G.,
Leite Heitor P
Publication year - 2019
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.13480
Subject(s) - medicine , interquartile range , end stage renal disease , calcification , blood pressure , cardiology , renal artery , kidney disease , vitamin d and neurology , kidney , disease
ABSTRACT Aim To investigate if calcification and intimal media thickness (IMT) of arteries are present in children and adolescents with end‐stage renal disease and to describe the risk factors associated with these alterations. Methods In an observational, cross‐sectional prospective study, 68 patients were evaluated at the time of renal transplantation. A fragment of the inferior epigastric artery was removed during surgery for histopathological analysis to verify the presence or not of arterial calcification. Two outcomes were considered: the presence of calcium deposition and the measurement of the IMT of the artery. The potential exposure variables were: age, chronic kidney disease aetiology, diagnosis time, systolic blood pressure (SBP), use of oral active vitamin D, homocysteine and C‐reactive protein. Results No arterial calcification was observed in the studied sample. The median value of the IMT of the inferior epigastric artery was 166 μm (interquartile range = 130–208). SBP standard deviation score and age were the only factors associated with this outcome. There was no statistical interaction between SBP and age with the IMT ( P = 0.280). Conclusion Arterial calcification is rare in children and adolescents with end‐stage renal disease. The factors associated with IMT were age and SBP.