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Lithium and nephrotoxicity: Unravelling the complex pathophysiological threads of the lightest metal
Author(s) -
Davis Justin,
Desmond Michael,
Berk Michael
Publication year - 2018
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.13263
Subject(s) - nephrogenic diabetes insipidus , medicine , nephrotoxicity , gsk 3 , pathophysiology , diabetes insipidus , nephropathy , glycogen synthase , endocrinology , kinase , cancer research , bioinformatics , diabetes mellitus , kidney , microbiology and biotechnology , glycogen , biology
Summary at a Glance This paper elucidated the current evidence pertaining to the pathophysiology of lithium induced nephrotoxicity and nephrogenic diabetes insipidus. The molecular mechanisms behind are the development of alterations in glycogen synthase kinase 3 signalling, G2 cell cycle progression arrest, alterations in inositol and prostaglandin signalling pathways, and dysregulated trafficking and transcription of aquaporin 2 water channels.