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Multicentre cross‐sectional study for bone‐articular lesions associated with dialysis related amyloidosis in Japan
Author(s) -
Nishi Shinichi,
Hoshino Junichi,
Yamamoto Suguru,
Goto Shunsuke,
Fujii Hideki,
Ubara Yoshifumi,
Motomiya Yoshihiro,
Morita Hiroyuki,
Takaichi Kenmei,
Yamagata Kunihiro,
Shigematsu Takashi,
Ueda Mitsuharu,
Ando Yukio
Publication year - 2018
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.13077
Subject(s) - medicine , carpal tunnel syndrome , spinal canal stenosis , dialysis , cross sectional study , joint pain , stenosis , surgery , physical therapy , pathology , spinal canal , psychiatry , spinal cord
Aim Dialysis‐related amyloidosis (DRA) exhibits multiple bone‐articular lesions, such as carpal tunnel syndrome (CTS), trigger finger (TF), spinal canal stenosis (SCS), destructive spondyloarthropathy (DSA), bone cysts, and joint pains. DRA leads to a decrease in activities of daily living (ADL). We investigated the initiation of CTS and TF, and evaluated the relationship between walking disturbances and bone‐articular lesions or joint pains. Methods A multicentre cross‐sectional study was performed. Eighty‐two patients with clinical DRA from 20 hospitals in Japan were evaluated. Results Of the 82 patients, the first symptom of DRA was CTS in 39 patients (47.6%) and TF in 21 (25.6%). The mean new‐onset vintages of 21 earlier cases in the CTS and TF groups were 86.1 ± 36.3 and 133.2 ± 56.4 (mean ± SD) months, respectively ( P = 0.0091). The development of SCS and DSA appeared to be later than CTS and TF. Multiple regression analysis revealed that knee joint pain was a significant contributor to walking disturbances. Conclusion Carpal tunnel syndrome appeared significantly earlier than TF since the initiation of dialysis. In the advanced phase, knee joint pain was a major cause of decreased ADL in patients with clinical DRA.