Premium
Subclinical atypical haemolytic uremic syndrome relapse following discontinuation of eculizumab
Author(s) -
Choo Shi Zhou,
Brown Fiona
Publication year - 2017
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12931
Subject(s) - eculizumab , medicine , discontinuation , atypical hemolytic uremic syndrome , thrombotic microangiopathy , haemolysis , haemolytic uraemic syndrome , subclinical infection , gastroenterology , acute kidney injury , pediatrics , immunology , complement system , antibody , biochemistry , chemistry , disease , escherichia coli , gene
Abstract A 25‐year‐old man presented with microangiopathic haemolytic anaemia and acute kidney injury. With a normal ADAMTS‐13 level, negative faecal shiga‐toxin test and strong family history of atypical haemolytic uremic syndrome, he was commenced on eculizumab to good clinical response. Subsequent genetic testing revealed a heterozygous complement factor H mutation. Eculizumab was discontinued after 44 months of treatment, and he relapsed within 6 months, with the first sign being downtrending haptoglobin levels, with no other markers of haemolysis or thrombocytopaenia, 5 weeks prior to development of acute kidney injury. He was recommenced on eculizumab and to date still remains on it. This case highlights the unusual pattern of relapse and discusses the considerations for eculizumab discontinuation in patients with stable atypical haemolytic uremic syndrome receiving maintenance therapy.