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Protective effect of mycophenolate mofetil on residual renal function in peritoneal dialysis patients: An open label feasibility study
Author(s) -
Wang Xiaoyang,
Zhang Xiaoxue,
Lu Shan,
Liu Dong,
Chen Genyang,
Dou Yanna,
Yuan Wenming,
Ma Shuang,
Li Yansheng,
Xiao Jing,
Zhao Zhanzheng
Publication year - 2017
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12910
Subject(s) - medicine , urology , renal function , peritoneal dialysis , mycophenolate , urine , urinary system , dialysis , transplantation
Aim This study aims to evaluate the safety of mycophenolate mofetil (MMF) and its effect on residual renal function (RRF) during peritoneal dialysis (PD). Methods This is a prospective, randomized study comprising 60 PD patients. The patients were assigned either to the MMF group (MMF dosage: 1.0–1.5 g/day in two divided doses for 6 months, followed by a dose of 0.5–0.75 g/day for another 6 months) or to the control group. The patients close monitoring for 1 year. Variables related to residual renal function, including urine volume, measured glomerular filtration rate (GFR), and renal Kt/V, were measured at four time points. Results There were no significant changes in urinary protein excretion in either group ( P > 0.05). The MMF group showed a significantly higher urine volume than the control group (955.38 ± 243.54 vs 786.15 ± 279.62 mL/day, P = 0.024). The renal kt/V was also significantly higher in the MMF group (0.59 ± 0.11 in MMF vs 0.50 ± 0.19 in control group, P = 0.032). There was significant difference in the renal measured GFR between the two groups at 6, 9 and 12 months (MMF vs control at 6 months, 6.14 ± 0.66 vs 5.58 ± 0.65 mL/min per 1.73m 2 , P = 0.003; at 9 months, 5.68 ± 0.80 vs 4.78 ± 0.75, P < 0.001; at 12 months, 5.44 ± 0.91 vs 4.43 ± 0.93, P < 0.001). MMF was well tolerated without any serious complications. Conclusion The use of MMF in PD patients tends to better preserve RRF.