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Expression patterns of CD56+ and CD16+ cells in renal transplant biopsies with acute rejection: Associations with microcirculation injuries and graft survival
Author(s) -
Dos Santos Daniela Cristina,
Saraiva Camara Niels Olsen,
David Daisa Silva Ribeiro,
Malheiros Denise Maria Avancini Costa
Publication year - 2017
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12897
Subject(s) - medicine , peritubular capillaries , pathology , microcirculation , immunohistochemistry , biopsy , transplantation
Background The study investigated whether immunohistochemical features of interstitial and glomerular CD56 and CD16 infiltrates – NK cells markers – could be associated with microcirculation injury scores – peritubular capillaritis (ptc) and glomerulitis (g) – and graft survival. Methods The research analyzed the immunohistochemical pattern of CD56 and CD16 in interstitial and glomerular compartments of biopsies for‐cause biopsies from 59 recipients diagnosed with acute rejection (mea n = 135.5 days post‐transplant). Results Interstitial CD56+ cells had an increased expression for glomerulitis (g ≥ 1) ( P = 0.02) and peritubular capillaritis (ptc ≥ 2) ( P = 0.003) presence. It was noted that interstitial CD56 + cells with mean above 0.56 cells/mm 2 had worse allograft survival. CD56+ cells in the interstitial compartment with mean less than or equal to 0.56cells/mm 2 was related with absence or mild peritubular capillaritis ( P = 0.012) and mean above 0.56 cells/mm 2 , respectively, with glomerulitis ( P = 0.002) presence. Interstitial CD16 cells showed greater positive results in relation to peritubular capillaritis ( P = 0.0001) cases. Similarly, it was observed that glomerular CD16+ cells had higher positive results in glomerulitis ( P = 0.009) presence. Conclusions The study findings showed that CD56+ cell infiltrated in the interstitial compartment was significantly associated with microcirculation injury scores, especially the glomerulitis, and graft survival.