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Correlation between subclinical hypothyroidism and renal function in patients with diabetes mellitus
Author(s) -
Zhang Lin,
Yang Guangran,
Su Zhiyan,
Yang Jinkui
Publication year - 2017
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12852
Subject(s) - medicine , subclinical infection , renal function , albuminuria , diabetes mellitus , gastroenterology , creatinine , thyroid function , endocrinology , univariate analysis , incidence (geometry) , type 2 diabetes mellitus , thyroid , multivariate analysis , physics , optics
Abstract Aim To evaluate the incidence of and risk factors for subclinical hypothyroidism (SCH) in patients with type 2 diabetes mellitus (T2D), and determine the association of SCH with renal function. Methods T2D patients hospitalized between June 2007 and July 2008 were cross‐section ally assessed. Clinical indicators and renal function were compared between the SCH and normal thyroid function groups. Risk factors for SCH and diabetic renal injury (albuminuria) were evaluated by univariate and multivariate analyses. Results Subclinical hypothyroidism prevalence was significantly higher in women, with a male to female ratio of 1:2.7. Age (62.56 ± 10.79 vs. 59.09 ± 10.82 years, P = 0.008), systolic blood pressure (138.80 ± 18.85 vs. 131.29 ± 16.97, P = 0.000), TC (5.22 ± 1.20 vs. 4.83 ± 1.03 mmol/L; P = 0.008), LDL‐C (3.35 ± 0.96 vs. 3.06 ± 0.87 mmol/L; P = 0.007), creatinine (84.54 ± 47.05 vs. 74.49 ± 29.96 µmol/L; P = 0.01), urinary albumin excretion rate [18.6 (7.58–326.78) vs. 10.69 (5.79–40.8) µg/min; P = 0.001], and thyrotropin [4.92 (4.37–6.27) vs. 1.4 (0.92–2.09) μIU/mL; P = 0.000] were significantly higher in the SCH group; meanwhile, TBIL (12.05 ± 5.20 vs. 13.98 ± 5.32 µmol/L; P = 0.008), DBIL (2.54 ± 1.20 vs. 2.88 ± 1.17 µmol/L; P = 0.033), IDBIL (9.51 ± 4.62 vs. 11.10 ± 4.72 µmol/L; P = 0.013), and total glomerular filtration rate [46.96 (35–68.26) vs. 71.74 (50.13–83.36) mL/min; P = 0.000] were significantly lower in SCH patients. Macroalbuminuria prevalence was significantly higher in the SCH group (18.2 vs. 11.4%; P < 0.001). Interestingly, SBP (OR = 1.050; 95%CI 1.034–1.066; P = 0.000), DR (OR = 5.248; 95%CI 2.816–9.777; P = 0.000), SCH (OR = 2.256; 95%CI 1.184–4.299; P = 0.013), and TC (OR = 1.389; 95%CI 1.108–1.742; P = 0.004) were found to be independent risk factors for macroalbuminuria. Conclusion These findings demonstrate an association of SCH with renal injury in diabetic patients.