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Serum sclerostin values are associated with abdominal aortic calcification and predict cardiovascular events in patients with chronic kidney disease stages 3–5D
Author(s) -
Wang XueRong,
Yuan Liang,
Zhang JingJing,
Hao Li,
Wang DeGuang
Publication year - 2017
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12813
Subject(s) - sclerostin , medicine , kidney disease , logistic regression , diabetes mellitus , gastroenterology , disease , calcification , endocrinology , cardiology , biochemistry , wnt signaling pathway , chemistry , gene
Aim The purpose of this study was to investigate the possible association of circulating concentrations of sclerostin with abdominal aortic calcification (AAC) and cardiovascular outcomes in patients with chronic kidney disease stage 3–5. Methods One hundred and sixty‐one patients with CKD3–5D were enrolled. The patients were divided into two groups according to the presence of AAC: an AAC group ( n = 99) and a non‐AAC group ( n = 62). The concentration of serum sclerostin was measured using an enzyme‐linked immunosorbent assay (ELISA). AAC was evaluated using abdominal lateral X‐ray examination. The follow‐up intervals ranged from 7 to 29 months (median 16 months), and cardiovascular events (CVEs) were recorded. Results The prevalence of vascular calcification (VC) was 61.5% (99/161). Serum sclerostin was significantly higher in an AAC group than in a non‐AAC group ( P < 0.001), but the concentration in the moderate‐to‐severe AAC group was lower than in the mild AAC group ( P < 0.001). Binary logistic regression analysis revealed that high serum sclerostin, high serum calcium, diabetes, and old age were independently correlated with AAC. Patients with higher sclerostin values had a reduced risk of major cardiovascular events (log‐rank test, P = 0.001). Conclusion Serum sclerostin values are associated with the presence of AAC, but are lower when AAC is moderate to severe. Higher values are predictive of reduced short‐term cardiovascular events. Taken together, these results suggest that sclerostin may have a role in the development of or the response to vascular calcification.