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Prolonged QT interval is linked to all‐cause and cardiac mortality in chronic peritoneal dialysis patients
Author(s) -
Kuo HueyLiang,
Liu YaoLung,
Liang ChihChia,
Chang ChizTzung,
Wang SuMing,
Liu JiungHsiun,
Lin HsinHung,
Wang IKuan,
Yang YaFei,
Chou CheYi,
Huang ChiuChing
Publication year - 2017
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12808
Subject(s) - medicine , qt interval , hazard ratio , peritoneal dialysis , cardiology , confidence interval , dialysis , proportional hazards model
Aim Prolonged QT interval is related to changes of electrolytes in haemodialysis (HD) and is associated with all‐cause mortality in HD patients. It is unknown if prolonged QT interval is associated with all‐cause mortality in peritoneal dialysis (PD) patients as the electrolytes were relatively stable in PD. We therefore investigated the association of prolonged QT interval and all‐cause mortality in chronic PD patients. Methods The QT intervals were measured in 2003 and all patients were followed to December 2012. A prolonged QT interval was defined as a QT interval > 450 ms. The association of prolonged QT interval with all‐cause and cardiac‐specific mortality was analyzed using Cox regression and Kaplan–Meier analysis. Results Of 306 patients, 196 (64%) patients had prolonged QT interval. The incidence density rate was 9.7 per 100 persons‐years for all‐cause mortality and 5.6 for cardiac specific mortality in patients with prolonged QT interval. Prolonged QT interval was associated with all‐cause mortality with a hazard ratio (HR) of 1.59 (95% confidence interval (CI): 1.06–2.39, P = 0.03] and cardiac mortality (HR: 1.66, 95% CI: 1.00–2.78, P = 0.05) with adjustments for age, gender, diabetes, and vintage of dialysis. Longer QT interval (>500 ms, 450–500 ms, and < 450 ms) was significantly associated with a worse overall survival ( P = 0.03, log‐rank test) and cardiac mortality free survival ( P = 0.05, log‐rank test). Conclusions Prolonged QT interval was associated with all‐cause and cardiac mortality in patients on peritoneal dialysis. The association is independent of patient's age and diabetes.