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Live donor study – implications of kidney donation on cardiovascular risk with a focus on lipid parameters including lipoprotein a
Author(s) -
Doucet Brian,
Kostner Karam,
Kaiser Omar,
Hawley Carmel,
Isbel Nicole
Publication year - 2016
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12792
Subject(s) - interquartile range , medicine , renal function , body mass index , lipoprotein , triglyceride , ethylenediaminetetraacetic acid , urology , endocrinology , cholesterol , chemistry , organic chemistry , chelation
In this prospective observational cohort study, we evaluate the change in cardiovascular risk parameters, with a focus on lipids, in live kidney donors 1 year post donation. Body mass index, systolic/diastolic blood pressure, kidney function (chromium‐51 ethylenediaminetetraacetic acid estimated glomerular filtration) and lipid parameters were measured at baseline and 1 year. Data on 87 live kidney donors were collected. Body mass index increased from 26.5 ± 2.7 pre to 27.4 ± 3.0 kg/m 2 post donation ( p < 0.0001). Chromium‐51 ethylenediaminetetraacetic acid estimated glomerular filtration decreased from 111.8 ± 20.0 pre to 72.1 ± 13.1 mL/min/1.73 m 2 post donation ( p < 0.0001). Serum triglyceride levels increased from 0.8 (interquartile range 0.6–1.3) pre to 1.0 mmol/L (interquartile range 0.7–1.6) post donation ( p = 0.0004). Statin use increased from 11.5% pre to 21% post donation ( p < 0.005). Low‐density lipoprotein remained stable, and other lipids (high‐density lipoprotein, apolipoprotein B and lipoprotein a) did not change post donation.