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Progression and outcomes of non‐dialysis dependent chronic kidney disease patients: A single center longitudinal follow‐up study
Author(s) -
Khan Yusra Habib,
Sarriff Azmi,
Adnan Azreen Syazril,
Khan Amer Hayat,
Mallhi Tauqeer Hussain,
Jummaat Fauziah
Publication year - 2017
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12713
Subject(s) - medicine , renal replacement therapy , dialysis , kidney disease , renal function , end stage renal disease , blood pressure , diabetes mellitus , hemodialysis , proteinuria , kidney , endocrinology
Aim Despite increase global prevalence of End stage renal disease (ESRD) and subsequent need for renal replacement therapy (RRT), relatively little is known about disease progression and prognosis of earlier stages of CKD. Current study was conducted to examine rate of CKD progression, predictors of ESRD and death. Methods A total 621 patients with estimated glomerular filtration rate (eGFR) of 15‐59ml/min/1.73m 2 (CKD stage 3 & 4) were selected and followed up for 10 years or until ESRD or death, whichever occurred first. Subjects who did not meet inclusion criteria were excluded (n=1474). Results Annual cumulative decline in eGFR was 3.01±0.40 ml/min/1.73m 2 . Overall disease progression was observed in 60% patients while 18% died. Among patients with CKD stage 3, 21% progressed to stage 4, 10% to stage 5ND (non‐dialysis) and 31% to RRT while mortality was observed in 16% patients. On the other hand, 8% patients with CKD stage 4 progressed to stage 5ND, 31% to RRT and mortality was observed in 24% cases. Patients with CVD, higher systolic blood pressure, elevated phosphate levels, heavy proteinuria, microscopic hematuria and use of diuretics were more likely to develop ESRD. Advancing age, low eGFR, low systolic blood pressure, low hemoglobin and baseline diabetes were found to be significant predictors of mortality while being female reduced risk of mortality. Conclusion Our data suggest that, in this CKD cohort, patients were more likely to develop ESRD than death. Prime importance should be given to mild forms of CKD to retard and even reverse CKD progression.