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Prevalence, determinants, and clinical significance of masked hypertension and white‐coat hypertension in patients with chronic kidney disease
Author(s) -
Tang Hua,
Gong WenYu,
Zhang QunZi,
Zhang Jun,
Ye ZengChun,
Peng Hui,
Wang Cheng,
Lou Tanqi
Publication year - 2016
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12672
Subject(s) - medicine , masked hypertension , white coat hypertension , blood pressure , cardiology , kidney disease , renal function , body mass index , ambulatory blood pressure
Background Masked hypertension and white‐coat hypertension have been studied among the general population and in hypertensive patients. However, little insight is available on masked and white‐coat hypertension among patients with chronic kidney disease (CKD). Methods We recruited 1322 CKD patients admitted to our hospital division. Patients were divided into four groups: normotension; white‐coat hypertension (WCHT); masked hypertension (MHT); sustained hypertension. Multivariable logistic regression analyses were used to evaluate the correlation between WCHT, MHT and renal/cardiovascular parameters. Results The prevalence of WCHT and MHT was 10.21% and 16.11%, respectively. Patients with WCHT and MHT had more severe target‐organ damage (TOD) than patients with normotension, but had less severe TOD than patients with sustained hypertension. MHT correlated with impaired renal function and left‐ventricular hypertrophy, whereas WCHT was associated with abnormal carotid intima media thickness. Age, body mass index, clinic and 24‐h systolic blood pressure correlated with MHT, whereas clinic, 24‐h diastolic blood pressure and night‐time systolic blood pressure was associated with WCHT. Conclusions Prevalence of WCHT and MHT was 10.21% and 16.11%, respectively. WCHT and MHT show a close relationship with TOD in CKD patients.