Premium
Development and function of Foxp3 + regulatory T cells
Author(s) -
Wang Yuan Min,
Ghali Joanna,
Zhang Geoff Yu,
Hu Min,
Wang Ya,
Sawyer Andrew,
Zhou Jimmy Jianheng,
Hapudeniya Dhanushka A.,
Wang Yiping,
Cao Qi,
Zheng Guoping,
Harris David C.,
Alexander Stephen I.
Publication year - 2016
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12652
Subject(s) - autoimmunity , foxp3 , limiting , medicine , immunology , peripheral tolerance , function (biology) , regulatory t cell , disease , autoimmune disease , t cell , microbiology and biotechnology , immune system , il 2 receptor , biology , antibody , pathology , mechanical engineering , engineering
Regulatory T cells (Tregs) have been recognized as having a major role in maintaining peripheral tolerance and preventing and limiting autoimmune and chronic inflammatory diseases. Tregs derive from the thymus and also develop peripherally. In this review, we discuss recent progress in our understanding of the basic mechanisms involved in Treg development and function in protecting against autoimmunity in the periphery, including thymic selection, peripheral induction and the many mechanisms of Treg suppression. Specifically in kidney disease, Tregs have been shown to play a role in limiting injury and may potentially have a therapeutic role.