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Health‐related quality of life in survivors of acute kidney injury: The P rolonged O utcomes S tudy of the R andomized E valuation of N ormal versus A ugmented L evel R eplacement T herapy study outcomes
Author(s) -
Wang Amanda Y,
Bellomo Rinaldo,
Cass Alan,
Finfer Simon,
Gattas David,
Myburgh John,
Chadban Steve,
Hirakawa Yoichiro,
Ninomiya Toshiharu,
Li Qiang,
Lo Serigne,
Barzi Federica,
Sukkar Louisa,
Jardine Meg,
Gallagher Martin P
Publication year - 2015
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12488
Subject(s) - medicine , renal function , quality of life (healthcare) , kidney disease , propensity score matching , renal replacement therapy , albuminuria , population , acute kidney injury , nursing , environmental health
Aim While patients with chronic kidney disease have reduced health‐related quality of life ( HRQOL ), long‐term HRQOL of survivors of severe acute kidney injury ( AKI ) remains unclear. Methods We analysed HRQOL from the P rolonged O utcomes S tudy of the R andomized E valuation of N ormal versus A ugmented L evel R eplacement T herapy ( POST‐RENAL ) study and compared findings with those from a general A ustralian adult population enrolled in the A ustralian D iabetes, O besity and L ifestyle ( A us D iab) study. We used a multivariate analysis adjusted for baseline characteristics along with sensitivity analysis using age and sex‐matched case controls. Results In the POST‐RENAL study, 282 participants had HRQOL data collected using the SF ‐12 questionnaire. This was compared with 6330 participants from the A us D iab study. Unadjusted analyses showed that POST‐RENAL participants had lower physical component scores ( PCS , mean score 40.0 vs 49.8, P < 0.0001) and lower mental component scores ( MCS , mean score 49.8 vs 53.9, P < 0.0001) than the A us D iab group. After age and sex matching, the difference in PCS and MCS remained statistically significant ( P < 0.0001). Advanced age, reduced renal function and albuminuria (all P ≤ 0.01) were all strongly associated with lower PCS values but not MCS values. After matching subsets of the cohorts on the basis of age, sex and renal function, PCS and MCS were lower in the POST‐RENAL group ( P < 0.0001). Conclusion Survivors of severe AKI in the POST‐RENAL study had lower physical and mental components of HRQOL compared with general population, even after adjustment for their reduced renal function. Increasing age and reduced renal function were associated with poorer physical QOL .