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Histological reversibility of diabetic nephropathy after kidney transplantation from diabetic donor to non‐diabetic recipient
Author(s) -
Harada Shumpei,
Ushigome Hidetaka,
Nishimura Ayako,
Nakao Toshimasa,
Nakamura Tsukasa,
Koshino Katsuhiro,
Suzuki Tomoyuki,
Itoh Takashi,
Nobori Shuji,
Yoshimura Norio
Publication year - 2015
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1111/nep.12451
Subject(s) - medicine , diabetic nephropathy , urology , diabetes mellitus , transplantation , kidney transplantation , kidney , endocrinology
Aim Given the recent increase in the prevalence of diabetes mellitus, it is not uncommon for kidney transplantation donors to have diabetes. We perform kidney transplantation in our hospital if the diabetic donors are receiving oral hypoglycaemic agents, but not insulin, and their haemoglobin A1C ( HbA1C ) is below 6.5%. There are few reports about histological changes to diabetic nephropathy after transplantation of kidney grafts from donors with diabetes mellitus to non‐diabetic recipients. Therefore, we studied the histological diabetic changes in grafts from diabetic donors at protocol biopsies (1 hour, 1 month, 1 year), and evaluated whether they improved under the recipient's good glycaemic control. Methods Three cases of kidney transplantation from donors with diabetes mellitus to non‐diabetic recipients were selected. We used a pathological classification established by the Renal Pathology Society for evaluating histological improvements in diabetic nephropathy. Results The results revealed that early diabetic changes found at the 1‐hour and 1‐month protocol biopsies were reversed and improved at the 1‐year biopsy. Conclusion We concluded that early diabetic changes in grafts from diabetic donors may improve if the graft recipient has good glycaemic control after kidney transplantation.